Agenda

	Program Schedule
	For session summaries click on the session titles

	Friday, May 17 2002
	3:00 -- 7:00 pm	Arrival and Registration
	7:30 -- 10:00 pm	Welcoming Reception (private invitation only)
	Saturday, May 18th 2002
	7:00 -- 8:30 am	Registration and Breakfast
	8:30 -- 8:45 am	Giovanna Spinella, MD -- Welcome and Opening Remarks
	8:45 -- 10:20 am	Session I – Neurochemistry Associated with Pediatric Neurotransmitter Diseases Darryl C. De Vivo, MD -- Chair
	8:45 -- 9:10 am	O.C. Snead, MD -- “Functional Aspects of GABA Neurotransmission”
	9:10 -- 9:40 am	Teodoro Bottiglieri, PhD -- “Biogenic Amines-Metabolism and Regulation”
	9:40 -- 10:05 am	O. C. Snead, MD -- “GHB: A Potential Neurotransmitter in Mammalian CNS”
	10:05 -- 10:20 am	Roundtable Discussion
	10:20 -- 10:35 am	Break
	10:35 -- 12:30 pm	Session II – Clinical Overview of PNDs Andrea Gropman, MD -- Chair
	10:35 -- 11:00 am	Kathryn Swoboda, MD -- “Aromatic L-Amino Acid Decarboxylase Deficiency”
	11:00 -- 11:25 am	George F. Hoffmann, MD -- “Tyrosine Hydroxylase Deficiency”
	11:25 -- 11:50 pm	Darryl C. De Vivo, MD -- “Segawa Disease (Dominantly Inherited GTP Cyclohydrolase Deficiency)
	11:50 -- 12:15 pm	Phillip Pearl, MD -- “Succinic Semialdehyde Dehydrogenase (SSADH) Deficiency (4-Hydroxybutyric Aciduria) in Children and Adults”
	12:15 -- 12:30 pm	Roundtable Discussion
	12:30 -- 1:30 pm	Lunch
	1:30 -- 4:10 pm	Session III -- Diagnoses and Therapeutic Intervention for PNDs Keith Hyland, PhD -- Chair
	1:30 -- 2:00 pm	George F. Hoffmann, MD -- “The Clinician’s Approach to the Diagnosis of the Patient with a Suspected PND”
	2:00 -- 2:30 pm	Keith Hyland, PhD -- “The Lumbar Puncture for Diagnosis of PNDs”
	2:30 -- 2:45 pm	Roundtable Discussion
	2:45 -- 3:00 pm	Coffee Break
	3:00 -- 3:30 pm	Blair Ford, MD -- “Therapeutic Intervention for Disorders of Biogenic Amine Metabolism”
	3:30 -- 3:55 pm	Andrea Gropman, MD -- “Vigabatrin and Newer Interventions in SSADH Deficiency”
	3:55 -- 4:10 pm	Roundtable Discussion
	4:10 -- 5:00 pm	Summary Discussion -- “Strategy Planning for Implementation of Goals and Objectives of the PND Association”-Chaired by the Scientific Organization Committee and Invited Speakers (open to all participants)
	5:00 pm	Adjourn
	7:30 pm	Conference Dinner (private invitation only)
	Sunday, May 19, 2002
	7:00 -- 8:00 am	Breakfast
	8:15 -- 9:50 am	Session IV – Animal Models of PNDs Kathryn Swoboda, MD -- Chair
	8:15 -- 8:40 am	Marc Caron, MD -- “Animal Models of Catecholamine Defects”
	8:40 -- 9:10 am	K. Michael Gibson, PhD -- “New Therapeutic Insights from a Murine Model of SSADH Deficiency”
	9:10 -- 9:35 am	Keith Hyland, PhD -- “The hph-1 Mouse, a Model of GTP Cyclohydrolase Deficiency”
	9:35 -- 9:50 am	Roundtable Discussion
	9:50 -- 10:05 am	Break
	10:05 -- 11:15 am	Session V -- Future Directions for Research And Treatment of PNDs G. Hoffmann, MD -- Chair
	10:05 -- 10:35 am	Markus Grompe, MD -- “The Potential Role of Hepatocyte Repopulation in Treating PNDs”
	10:35 -- 11:05 am	Clive Svendsen, PhD – “Genetic Modification of Human Neuronal Stem Cells; Implications for Brain Repair”
	11:05 -- 11:15 am	Roundtable Discussion
	11:15 -- 12:10 pm	Summary Discussion -- “What are the Future Objectives of the PND Association, and How Do We Coordinate to Achieve Our Goals”-Chaired by the Scientific Organizing Committee and Invited Speakers (open to all participants)
	12:10 -- 12:25 pm	Giovanna Spinella, MD and Darryl C. De Vivo, MD --Concluding Remarks and Closing
	12:30 pm	Adjourn